Thermo Fisher Scientific TNFSF15 Monoclonal Antibody (3H3)
TNFSF15 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot과 ELISA에 최적화되어 있습니다. 인간 시료에 반응하며, PBS(pH 7.4)에 보존된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3H3 |
| Immunogen | TNFSF15 (AAH74941.1, 72 a.a. approximately 251 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
LKGQEFAPSH QQVYAPLRAD GDKPRAHLTV VRQTPTQHFK NQFPALHWEH ELGLAFTKNR MNYTNKFLLI PESGDYFIYS QVTFRGMTSE CSEIRQAGRP NKPDSITVVI TKVTDSYPEP TQLLMGTKSV CEVGSNWFQP IYLGAMFSLQ EGDKLMVNVS DISLVDYTKE DKTFFGAFLL
Target Information
The protein encoded by this gene is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It is abundantly expressed in endothelial cells, but not in B or T cells. Expression is inducible by TNF and IL-1α.
This cytokine acts as a ligand for TNFRSF25 and decoy receptor TNFRSF21/DR6, activating NF-κB and MAP kinases. It functions as an autocrine factor inducing apoptosis in endothelial cells and inhibits endothelial cell proliferation, potentially serving as an angiogenesis inhibitor.
An additional isoform from an alternatively spliced transcript variant has been reported, though its sequence has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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