Thermo Fisher Scientific RUVBL2 Polyclonal Antibody
Thermo Fisher Scientific의 RUVBL2 Polyclonal Antibody는 인간 RUVBL2 단백질을 인식하는 토끼 IgG 항체입니다. Western blot, IHC, ICC/IF에 적합하며, NuA4 복합체 관련 연구 및 DNA 수선, 전사 조절 연구에 활용됩니다. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공됩니다.
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- PA5111628
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,500–1:5,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RUVBL2. Recombinant protein control fragment (Product #RP-105442) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2857038 |
Product Specific Information
Immunogen sequence:
ATVTDTTKVP EIRDVTRIER IGAHSHIRGL GLDDALEPRQ ASQGMVGQLA ARRAAGVVLE MIREGKIAGR
Target Information
RUVBL2 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5′ to 3′) activity. It is a component of the NuA4 histone acetyltransferase complex, which is involved in transcriptional activation of select genes primarily through acetylation of nucleosomal histones H4 and H2A. This modification alters nucleosome–DNA interactions and promotes interaction with other proteins that positively regulate transcription.
The NuA4 complex contributes to transcriptional programs associated with oncogene-mediated growth induction, tumor suppressor-mediated growth arrest, replicative senescence, apoptosis, and DNA repair. RUVBL2, together with RUVBL1 and EP400, contributes ATPase and helicase activities within the complex.
RUVBL2 also plays a role in DNA repair at damage sites, is essential for MYC-mediated oncogenic transformation, modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex, and may inhibit ATF2 transcriptional activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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