Thermo Fisher Scientific Chk2 Polyclonal Antibody
Rabbit 폴리클로날 항체로 CHK2 단백질을 특이적으로 인식. Western blot 및 Immunoprecipitation에 적합. 액상 형태로 4°C 보관, 권장 유효기간 1년. DNA 손상 체크포인트 연구 및 암 관련 단백질 인산화 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 500 and the C-terminus (residue 543) of human Checkpoint Kinase 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 are linked to various cancers. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control, including tumor suppressor proteins. It also phosphorylates BRCA1, facilitating DNA damage repair. CHK2 functions as a putative tumor suppressor, with mutations associated with Li-Fraumeni syndrome and increased predisposition to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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