Thermo Fisher Scientific Phospho-CDK1 (Tyr15) Monoclonal Antibody (M231)
CDK1의 Tyr15 인산화 상태를 검출하는 단일클론 항체로, 인간·마우스·랫 시료에 반응합니다. Western blot에 적합하며, 비인산화형과 구별이 가능합니다. 단백질 A로 정제된 액상 항체로, -20°C에서 보관합니다.
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Applications
- Western Blot (WB): 1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M231 |
| Immunogen | Clone M231 was generated from a phospho-Cdk1 (Tyr-15) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding Tyr-15 in human Cdk1. This sequence is conserved in rat and mouse Cdk1, and is highly conserved in other Cdks, including Cdk2, Cdk3, Cdk5, and Cdk6. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2942602 |
Product Specific Information
The antibody detects a 34 kDa band corresponding to Cdk1 on SDS-PAGE immunoblots of human SYF and HeLa cells, and this band is removed after alkaline phosphatase treatment. The antibody may also detect Tyr-15 phosphorylation in Cdk2, Cdk3, Cdk5, and Cdk6.
Target Information
CDK1 (Cell Division Control protein 1) is essential for the completion of START, the controlling event in the cell cycle required to initiate mitosis. CDK1 acts as the catalytic subunit of the M-Phase Promoting Factor, which induces entry into mitosis and is conserved among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays apoptosis onset. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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