Thermo Fisher Scientific STIM2 Polyclonal Antibody
STIM2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 사용 가능. Human 및 Mouse 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 4°C에서 보관하며 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 650 to 700 of Human Stromal Interaction Molecule 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
In T lymphocytes, the sole pathway for Ca²⁺ entry following antigen-receptor binding is through store-operated Ca²⁺-release-activated Ca²⁺ (CRAC) channels. These channels are composed of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), which acts as a Ca²⁺ sensor and activates CRAC channels by migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites.
A related molecule, STIM2, inhibits STIM1-mediated Ca²⁺ entry and can form complexes with STIM1, suggesting a coordinated role in Ca²⁺ regulation. At least three isoforms of STIM2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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