Thermo Fisher Scientific Human BRAF, GST Tag Recombinant Protein

Thermo Fisher Scientific Human BRAF, GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, please spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
• For larger sizes, aliquoting may reduce freeze/thaw cycles; aliquots below 20 µL are not recommended.
• Never store kinase diluted.
• Properly stored at -80°C, product is guaranteed for 6 months from date of purchase.
• Protein Form: Full Length

Target Information

BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer and plays a role in postsynaptic responses of hippocampal neurons. This protein regulates the MAP kinase/ERKs signaling pathway, influencing cell division, differentiation, and secretion.
Mutations in B-Raf have been associated with various cancers, including:

• Non-Hodgkin lymphoma
• Colorectal cancer
• Malignant melanoma
• Thyroid carcinoma
• Non-small cell lung carcinoma
• Adenocarcinoma of lung

A pseudogene located on chromosome X has been identified for B-Raf.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.