Thermo Fisher Scientific BRAP Polyclonal Antibody

Applications

Western Blot (WB)

• Assay-dependent

Immunoprecipitation (IP)

• 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

BRAP negatively regulates MAP kinase activation by limiting formation of Raf/MEK complexes, likely through inactivation of the KSR1 scaffold protein. It also acts as a Ras-responsive E3 ubiquitin ligase that, upon Ras activation, undergoes auto-polyubiquitination leading to release of inhibition of Raf/MEK complex formation. Additionally, it may function as a cytoplasmic retention protein involved in regulating nuclear transport.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.