Thermo Fisher Scientific BRAP Polyclonal Antibody
BRAP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 560 and 592 of human BRCA1 associated protein (BRAP) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
BRAP negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes, probably through inactivation of the KSR1 scaffold protein. It also acts as a Ras-responsive E3 ubiquitin ligase that, upon Ras activation, undergoes auto-polyubiquitination, releasing inhibition of Raf/MEK complex formation. Additionally, it may function as a cytoplasmic retention protein involved in regulating nuclear transport.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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