Thermo Fisher Scientific QKI Recombinant Rabbit Monoclonal Antibody (1D1N6)
QKI 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot, IHC, ICC, ELISA, IP에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, HEK293 세포에서 발현되었습니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1D1N6 |
| Immunogen | Synthetic peptide corresponding to amino acids 242–341 of human QKI (UniProt ID: Q96PU8) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C; avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911730 |
Product Specific Information
- Positive test controls: SKOV3, NIH/3T3, U-251MG, Neuro-2a, Mouse brain, Rat brain, Rat heart
- Subcellular localization: Cytoplasm, Nucleus
Immunogen sequence:
RTPTPAGPTI MPLIRQIQTA VMPNGTPHPT AAIVPPGPEA GLIYTPYEYP YTLAPATSIL EYPIEPSGVL GAVATKVRRH DMRVHPYQRI VTADRAATGN
Target Information
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. It is highly expressed in the central nervous system, and also found in skin, skeletal muscles, and at low levels in the pancreas. The gene includes a large exon spanning more than 12.8 kb. Mutations in this gene cause autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. Sacsin protects against mutant ataxin-1. A pseudogene is located on chromosome 11, and alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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