Thermo Fisher Scientific ITGB1BP1 Polyclonal Antibody
Rabbit Polyclonal Antibody targeting Human ITGB1BP1. Validated for WB and ICC/IF. Provides high specificity and affinity through antigen affinity purification. Suitable for studies on integrin-mediated signaling, cell adhesion, and migration. For resea...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ITGB1BP1. Recombinant protein control fragment (Product #RP-105536) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662038 |
Product Specific Information
Immunogen sequence:
SRSSTVASLDT DSTKSSGQSN NNSDTCAEFR IKYVGAIEK
Highest antigen sequence identity to the following orthologs:
- Mouse: 95%
- Rat: 95%
Target Information
ITGB1BP1 is a key regulator of integrin-mediated cell–matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing activation of integrin α5β1 by talin or FERMT1. It plays roles in:
- Cell proliferation, differentiation, spreading, adhesion, and migration
- Bone development and angiogenesis
- Regulation of β1 integrin-containing focal adhesion site dynamics
- Control of osteoblast spreading and migration in fibronectin/collagen-dependent contexts
- Regulation of Rho family GTPases (CDC42, RAC1) during integrin-mediated adhesion
- ROCK1 translocation and increased myoblast migration on laminin
- Bone mineralization at late osteoblast differentiation stages
- Negative regulation of angiogenesis via Notch signaling and modulation of AKT/ERK1/2 phosphorylation
- Promotion of MYC promoter transcriptional activity
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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