Thermo Fisher Scientific SOX17 Monoclonal Antibody (OTI3H5)
SOX17 단백질을 인식하는 Mouse 모노클로날 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Human 및 Dog 반응성을 가지며, 고순도 Affinity Chromatography 정제 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,500–1:5,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Published Species | Marsupial |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3H5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 177–414 of SOX17 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.61 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725397 |
Target Information
SOX17 (transcription factor SOX-17) belongs to the SRY-related HMB box family of transcription factors.
It acts as a transcription regulator that binds target promoter DNA and bends the DNA.
It binds to the sequences 5'-AACAAT-3' or 5'-AACAAAG-3'.
SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling.
It promotes degradation of activated CTNNB1.
SOX17 plays an essential role in the regulation of embryonic development and is required for normal looping of the embryonic heart tube and for normal development of the definitive gut endoderm.
Mutations in the gene can result in vesicoureteral reflux.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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