Thermo Fisher Scientific SOX17 Monoclonal Antibody (OTI3B10)
SOX17 단백질을 인식하는 Thermo Fisher의 마우스 단클론 항체로, WB, IHC, ICC/IF에 적합. 높은 특이성과 재현성을 제공하며, 인간 시료 반응성 확인됨. 액상 형태로 -20°C 보관, 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 177–414 of SOX17 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725396 |
Target Information
SOX17 (transcription factor SOX-17) belongs to the SRY-related HMB box family of transcription factors.
It acts as a transcription regulator that binds target promoter DNA and bends the DNA.
It binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-'3.
SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling.
It promotes degradation of activated CTNNB1 and plays an essential role in embryonic development, including normal looping of the embryonic heart tube and definitive gut endoderm formation.
Mutations in the gene can result in vesicoureteral reflux.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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