Thermo Fisher Scientific CD104 Monoclonal Antibody (CL6972)
인간 CD104(Integrin β4)을 인식하는 Mouse monoclonal antibody(CL6972). Western blot 및 IHC(파라핀 절편)에 적합. Protein A 정제, PBS/glycerol buffer에 보관. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL6972 |
| Immunogen | Recombinant protein corresponding to Human CD104 (Integrin beta 4), UniProt ID: P16144-1, amino acids 1270–1356 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2848943 |
Product Specific Information
Immunogen sequence:
MKKVLVDNPK NRMLLIENLR ESQPYRYTVK ARNGAGWGPE REAIINLATQ PKRPMSIPII PDIPIVDAQS GEDYDSFLMY SDDVLRS
Target Information
Integrins are heterodimers composed of alpha and beta subunits that form noncovalently associated transmembrane glycoprotein receptors. Different alpha-beta combinations determine ligand-binding specificity. Integrins mediate cell–matrix and cell–cell adhesion and transduce signals regulating gene expression and cell growth.
The integrin beta 4 subunit acts as a receptor for laminins, commonly associating with the alpha 6 subunit. It plays a crucial role in invasive carcinoma biology. Mutations in this gene are linked to epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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