Thermo Fisher Scientific CD4 Monoclonal Antibody (SK3 (SK-3)), PE-Cyanine7, eBioscience
인간 CD4 항원을 인식하는 SK3 클론 단일클론 항체로, PE-Cyanine7 형광체가 결합된 제품입니다. Flow cytometry용으로 최적화되어 있으며 HIV 수용체 연구에 활용 가능합니다. 빛에 민감하므로 암조건에서 보관하며, 4°C에서 보관 권장.
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Thermo Fisher Scientific CD4 Monoclonal Antibody (SK3 (SK-3)), PE-Cyanine7, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.06 µg)/test
Publications: View 12 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE-Cyanine7, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SK3 (SK-3) |
| Conjugate | PE-Cyanine7 |
| Excitation / Emission Max | 569 / 780 nm |
| Form | Liquid |
| Concentration | 5 µL / Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10547896 |
Available Formats
- Alexa Fluor 532, 700
- APC, APC-eFluor 780
- Brilliant UV/Violet/Yellow series
- eFluor 450, FITC, PE, PE-Cyanine5.5, PE-eFluor 610
- PerCP-eFluor 710, Super Bright series
- NovaFluor Blue/Red/Yellow variants
- Request custom conjugation
Product Specific Information
Description:
The SK3 monoclonal antibody reacts with human CD4, a 59-kDa cell surface receptor expressed by thymocytes, mature T helper cells, and at low levels on monocytes. CD4 acts as a receptor for HIV, and SK3 blocks HIV binding and mixed lymphocyte reactions. SK3 and RPA-T4 recognize distinct epitopes.
Applications Reported:
Validated for flow cytometric analysis.
Applications Tested:
Pre-titrated for flow cytometry using normal human peripheral blood cells. Recommended use at 5 µL (0.06 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).
Light Sensitivity:
Protect vial and stained samples from light; tandem dye is photo-sensitive.
Fixation:
Samples can be stored in IC Fixation Buffer (Product # 00-822-49) or 1-step Fix/Lyse Solution (Product # 00-5333-54) for up to 3 days at 4°C in dark conditions.
Excitation / Emission / Laser:
488–561 nm excitation; 775 nm emission; compatible with Blue, Green, and Yellow-Green lasers.
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
CD4 antigen facilitates recognition of MHC class II molecules and serves as a co-receptor for HIV. It is primarily expressed on T helper cells, but also on monocytes, macrophages, and dendritic cells. CD4 expression is found in thymus, lymph nodes, tonsils, spleen, and certain non-lymphoid tissues. It plays a role in T-cell activation and may mediate neuronal damage in immune-related CNS diseases.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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