Thermo Fisher Scientific SRC Monoclonal Antibody (M259)
SRC 단백질을 인식하는 Mouse monoclonal antibody (Clone M259). Western blot 및 Immunoprecipitation에 최적화. 인간, 마우스, 랫트 반응성. Protein A 정제, 액상 형태, -20°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific SRC Monoclonal Antibody (M259)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1000 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M259 |
| Immunogen | Recombinant protein containing amino acids in the N-terminal region of human c-Src (high homology with rat and mouse c-Src) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942719 |
Product Specific Information
This antibody detects a 60 kDa protein corresponding to c-Src on SDS-PAGE immunoblots of mouse SYF cells transformed with c-Src and human A431 cells.
Target Information
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. It regulates growth and differentiation of eukaryotic cells and associates with cytoplasmic regions of various cell surface receptors to facilitate signal transduction. SRC also plays roles in cytoskeletal organization, cell cycle regulation, and apoptosis.
In humans, the SRC gene is located on chromosome 20. Its activity is regulated by two tyrosine residues (Tyr416 and Tyr527), with phosphorylation at Tyr416 activating and Tyr527 inhibiting the kinase. Mutations in SRC may contribute to malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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