Thermo Fisher Scientific SPHK1 Monoclonal Antibody (M540)
SPHK1 단백질 검출용 Rat monoclonal 항체(M540)로, Western blot 및 Immunocytochemistry에 사용 가능. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 -20°C 보관, 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:250
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rat |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M540 |
| Immunogen | Clone M540 was generated from a SK1 synthetic peptide (coupled to carrier) corresponding to amino acids in the C-terminal region of mouse SK1. This sequence has high homology to human and rat SK1, and is not homologous to sequences in SK2. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2942717 |
Product Specific Information
The antibody detects 42 kDa full-length recombinant human and mouse SK1 proteins, as well as 42, 50, and 60 kDa forms of SK1 in human HeLa cells.
Target Information
SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P).
S1P signals through G-protein coupled receptors and controls diverse cellular processes.
Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer.
SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P), an important signaling molecule with intra- and extracellular functions.
Inside the cell, S1P acts as a signaling molecule similar to other sphingolipid metabolites like ceramide and sphingosine.
S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis.
The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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