Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17), eFluor 506, eBioscience
인간 IL-17A를 인식하는 중화성 단클론 항체로, eFluor 506 형광체가 결합되어 있습니다. Flow cytometry 및 intracellular staining에 최적화되어 있으며, 염증 관련 질환 연구에 활용됩니다. 4°C에서 보관하며 냉동 금지.
- 카탈로그번호
- 69-7179-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17), eFluor 506, eBioscience
Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17), eFluor 506, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 3 publications |
| Flow Cytometry (Flow) | 5 µL (0.125 µg)/test | View 21 publications |
| ELISA | - | View 4 publications |
| Neutralization | - | View 1 publication |
| Radioimmune Assays (RIA) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Fungi, Hamster, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor™ 506, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio64DEC17 |
| Conjugate | eFluor™ 506 |
| Excitation / Emission Max | 419 / 508 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
| RRID | AB_2637320 |
Available Formats
- Unconjugated
- Alexa Fluor 488
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 563 / 737 / 805
- Brilliant Violet 605 / 786
- eFluor 450 / 660
- FITC
- PE / PE-Cyanine7 / PE-eFluor 610
- PerCP-Cyanine5.5
- Request custom conjugation
Product Specific Information
The eBio64DEC17 antibody reacts with human IL-17A and functions as a neutralizing antibody. IL-17A is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. It exists as glycosylated 20–30 kDa homodimers produced by activated peripheral blood CD4+ T cells.
IL-17A enhances ICAM-1 expression in fibroblasts and induces secretion of IL-6, IL-8, G-CSF, and PGE2 from epithelial and endothelial cells. It also supports proliferation and maturation of CD34+ hematopoietic progenitors into neutrophils.
IL-23-dependent, IL-17A-producing CD4+ T cells (Th17 cells) represent a distinct subset negatively regulated by Th1 and Th2 cytokines (IFN-γ and IL-4). Intracellular staining by eBio64DEC17 identifies the same population as eBio64CAP17.
Applications Reported: Intracellular staining followed by flow cytometric analysis.
Applications Tested: Pre-titrated and validated using the Intracellular Fixation and Permeabilization Buffer Set (Product # 88-8824-00). Use at 5 µL (0.125 µg) per test (100 µL final volume).
Fluorochrome Information:
- Excitation: 405 nm
- Emission: 506 nm
- Recommended filter: 510/20 band pass
- Laser: Violet
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses and signals through IL-17R/CDw217. It is a 32 kDa disulfide-linked homodimer of 136 amino acids, part of the IL-17 family (A–F). IL-17A enhances ICAM-1 expression and stimulates secretion of IL-6, IL-8, G-CSF, and PGE2, regulating NF-κB and MAPK pathways and promoting COX-2 and nitric oxide production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.