Thermo Fisher Scientific CD202b (TIE2) Polyclonal Antibody
CD202b (TIE2) 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot 및 면역세포염색(ICC/IF)에 적합하며, TEK 유래 합성 펩타이드로부터 제조되었습니다. 액상 형태로, PBS와 글리세롤 용액에 보관됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TEK (Accession Q02763), corresponding to amino acid residues E872–T922 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900676 |
Product Specific Information
This antibody detects endogenous levels of total TIE2.
Target Information
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling is critical for endothelial cell–smooth muscle cell communication during venous morphogenesis, and defects in TEK are associated with inherited venous malformations.
Angiopoietin-1 binds to this receptor and mediates a signaling pathway involved in embryonic vascular development. Immunoblotting studies have shown that TIE2 expression increases in response to thyroid-stimulating hormone and agents that elevate intracellular cAMP.
Hematopoietic stem cells (HSCs) expressing TIE2 are quiescent, anti-apoptotic, and form a side population that adheres to osteoblasts in the bone marrow niche.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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