Thermo Fisher Scientific GRPR Polyclonal Antibody
Human GRPR 인식 Rabbit Polyclonal Antibody로 IHC 및 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 인간 췌장 및 랑게르한스섬을 양성 대조로 권장. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: -
- Publications: View 6 publications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 4 µg/mL
- Publications: View publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH, corresponding to the 2nd extracellular loop of human GRPR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2114349 |
Product Specific Information
- Recommended positive controls: Human pancreas, islets of Langerhans
- By immunohistochemistry, OPA1-15619 detects GRPR in formalin fixed, paraffin embedded human tissues
Target Information
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. It is a potent mitogen for neoplastic tissues.
The effects of GRP are mediated through the gastrin-releasing peptide receptor (GRPR), a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway.
The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate.
An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the GRPR gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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