Thermo Fisher Scientific RIG-I Polyclonal Antibody
RIG-I 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, 1.0 mg/mL 농도의 액상 형태. 인간 및 비인간 영장류 반응성, 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2–4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acid 200–250 of human RIG-I |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| RRID | AB_2540997 |
Target Information
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor (PRR) involved in the recognition of viral double-stranded RNA (dsRNA). Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response. Both MDA5 and RIG-I are RNA helicases with overlapping and distinct roles.
RIG-I is activated by dsRNAs without a 5’-triphosphate end and short dsRNAs, whereas MDA5 is activated by long dsRNAs. Once activated, both proteins signal through IPS-1, activating transcription factors NF-kappaB and IRF-3, leading to apoptosis, cytokine signaling, and inflammation.
RIG-I is essential for signaling by influenza A and B, human respiratory syncytial virus, paramyxoviruses, Japanese encephalitis virus, and West Nile virus. MicroRNA-146a negatively regulates RIG-I targets TRAF6, IRAK1, and IRAK2, providing feedback inhibition of antiviral response. Recent evidence also implicates RIG-I in the detection of cytosolic DNA through RNA polymerase III activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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