Thermo Fisher Scientific CD16/CD32 Monoclonal Antibody (01)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Rhesus CD16/FCGR3.

Target Information

CD16 is a 50–65 kDa cell surface molecule that exists in two forms — a transmembranous form expressed by natural killer (NK) cells and some T cells, and a phosphatidylinositol-linked form expressed by granulocytes.
CD16 is a low-affinity receptor for IgG (FcR III) and is an important receptor mediating ADCC (antibody-dependent cell-mediated cytotoxicity) by NK cells.

In comparison, CD32 is a 40 kDa glycoprotein that acts as a low-affinity receptor for IgG (Fc gamma RII) and mediates several functions including endocytosis, activation of secretion, cytotoxicity, and immunomodulation.
CD32 is expressed by B cells, monocytes, granulocytes, and platelets. It is involved in the phagocytosis of immune complexes and the regulation of antibody production by B cells. Variations in the CD32 gene may increase vulnerability to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms of CD32 have been found.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.