Thermo Fisher Scientific CD16/CD32 Monoclonal Antibody (05)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Rhesus CD16/Fc gamma RIII.

Target Information

CD16 is a 50–65 kDa cell surface molecule that exists in two forms: a transmembranous form expressed by natural killer (NK) cells and some T cells, and a phosphatidylinositol-linked form expressed by granulocytes.
CD16 is a low affinity receptor for IgG (FcR III) and is an important receptor mediating ADCC (antibody-dependent cell-mediated cytotoxicity) by NK cells.

CD32 is a 40 kDa glycoprotein acting as a low affinity receptor for IgG (Fc gamma RII). It mediates functions such as endocytosis, activation of secretion, cytotoxicity, and immunomodulation. CD32 is expressed by B cells, monocytes, granulocytes, and platelets. It is involved in phagocytosis of immune complexes and regulation of antibody production by B cells. Variations of the CD32 gene may increase susceptibility to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms of CD32 have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.