Thermo Fisher Scientific CD11b Monoclonal Antibody (ICRF44), FITC, eBioscience
인간 CD11b를 인식하는 ICRF44 클론의 FITC 결합 단일클론 항체로, 유세포분석(Flow Cytometry)에 최적화됨. 다양한 영장류에 반응하며, 488 nm 여기/520 nm 방출 특성. PBS 기반 완충액에 0.09% sodium azide 포함, 4°C 암소 보관.
- 카탈로그번호
- 11-0118-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD11b Monoclonal Antibody (ICRF44), FITC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 5 µL (0.5 µg)/test | View 57 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Baboon, Chimpanzee, Cynomolgus monkey, Human, Rhesus monkey |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICRF44 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1582243 |
Additional Available Formats
Unconjugated, Alexa Fluor 700, APC, APC-eFluor 780, Biotin, Brilliant UV/Violet series, eFluor 506, NovaFluor Blue/Red/Violet/Yellow series, PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610, PerCP-eFluor 710, Super Bright series.
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Product Specific Information
The ICRF44 monoclonal antibody reacts with human CD11b, a 165 kDa adhesion molecule. CD11b, in association with integrin beta2 (CD18), is expressed on monocytes, granulocytes, activated lymphocytes, and a subset of NK cells. It serves as a receptor for intercellular adhesion molecules (CD54, CD102, CD50) and iC3b, playing a critical role in cell-cell and cell-matrix interactions.
- Applications Reported: Flow cytometric analysis.
- Applications Tested: Pre-titrated and validated for flow cytometry on human peripheral blood cells.
Recommended use: 5 µL (0.5 µg) per test (100 µL final volume; 10⁵–10⁸ cells/test). - Excitation: 488 nm
- Emission: 520 nm
- Laser: Blue Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD11b (Integrin alpha-M, ITGAM) is a 165 kDa adhesion molecule that forms a heterodimer with CD18 (integrin beta-2), known as Mac-1 or CR3. It is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, NK cells, dendritic cells, and microglia.
CD11b/CD18 acts as a receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X, mediating crucial adhesion processes.
Expression levels vary across tissues and increase during monocyte maturation. Dysregulation of CD11b is linked to systemic lupus erythematosus and related autoimmune conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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