Thermo Fisher Scientific USP7 Polyclonal Antibody
Thermo Fisher Scientific의 USP7 Polyclonal Antibody는 인간 USP7(HAUSP) 단백질을 인식하는 토끼 유래 다클론 항체입니다. Western blot에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide TDDPPRITQNPVC, corresponding to amino acids 30–41 of Human HAUSP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.72 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2214158 |
Product Specific Information
PA1-31831 detects HAUSP from human samples.
Target Information
USP7 (also known as HAUSP) is a ubiquitin-specific protease or deubiquitylating enzyme that removes ubiquitin from its substrates. Since ubiquitination is often associated with protein degradation, HAUSP activity generally stabilizes its substrate proteins. HAUSP is a known antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein p53. By deubiquitinating p53, HAUSP can protect it from Mdm2-mediated degradation, suggesting a tumor-suppressive role in stress response. HAUSP may also contribute to oncogenic stabilization of p53 through alternative pathways independent of ARF.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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