Thermo Fisher Scientific Amyloid Precursor Protein Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunoprecipitation (IP)

• Tested Dilution: Neat

Product Specifications

Product Specific Information

PA1-33107 detects APP from human, monkey, and mouse samples.

Target Information

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide (40–43 amino acids) is generated from the beta-amyloid precursor protein (beta APP) through a two-step cleavage process involving beta-secretase (BACE) and gamma-secretase.
Gamma-secretase is a multi-subunit complex containing presenilin-1 and 2 as central components, and nicastrin as an associated transmembrane glycoprotein that modulates amyloid beta production.
Abeta is found in amyloid cores, neuritic plaques, and neurofibrillary tangles, characteristic of Alzheimer’s disease and also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis, and the Guam Parkinson-Dementia complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.