Thermo Fisher Scientific Amyloid Precursor Protein Polyclonal Antibody
Thermo Fisher의 Amyloid Precursor Protein Polyclonal Antibody는 인간, 원숭이, 마우스 샘플에서 APP 검출에 적합합니다. Western blot 및 IP에 사용 가능하며, 액상 형태로 제공됩니다. Alzheimer 연구용으로 최적화된 고품질 항체입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunoprecipitation (IP)
- Tested Dilution: Neat
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Proprietary immunogen |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1956112 |
Product Specific Information
PA1-33107 detects APP from human, monkey, and mouse samples.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide (40–43 amino acids) is generated from the beta-amyloid precursor protein (beta APP) through a two-step cleavage process involving beta-secretase (BACE) and gamma-secretase.
Gamma-secretase is a multi-subunit complex containing presenilin-1 and 2 as central components, and nicastrin as an associated transmembrane glycoprotein that modulates amyloid beta production.
Abeta is found in amyloid cores, neuritic plaques, and neurofibrillary tangles, characteristic of Alzheimer’s disease and also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis, and the Guam Parkinson-Dementia complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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