Thermo Fisher Scientific ATM Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1/100–1/200

Product Specifications

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene codes for a protein in the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins rather than lipids and regulates cell-cycle proteins including P53, Mdm2, BRCA1, and SMC1.
ATM repairs double-stranded DNA breaks caused by ionizing radiation and mutagens. Its C-terminal region shares homology with catalytic domains of PI3 kinases. ATM becomes autophosphorylated and upregulated upon exposure to ionizing radiation.
AT cells are hypersensitive to radiation, show impaired DNA synthesis inhibition, and delayed p53 induction. DNA damage activates ATM-kinase, triggering kinase cascades that regulate cell cycle, apoptosis, and DNA damage repair.
ATM is also linked to apoptosis through interactions with Nbs1 and Chk2 in the E2F1 pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.