Thermo Fisher Scientific HPK1 Polyclonal Antibody
Human HPK1 단백질을 표적으로 하는 Rabbit Polyclonal Antibody. Western Blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 4°C에서 보관. 연구용으로만 사용.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 550 and 600 of human hematopoietic progenitor kinase 1 (HPK1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
Target Information
MAP4K1 (also known as HPK1, Hematopoietic progenitor kinase 1) is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase superfamily.
It acts as a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway and diminishes T cell receptor (TCR) signaling and T cell proliferation by phosphorylating adaptor protein SLP-76.
HPK1 is expressed predominantly in hematopoietic cells, including early progenitor cells, and specifically activates JNK1, enhancing AP-1-mediated transcriptional activity.
Unlike PAK65, HPK1 does not bind to small GTPases Rac1 or Cdc42, indicating a distinct regulatory mechanism within the MAPK cascade.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: A301-918A_HPK1_Q92918-1_Rabbit.svg / A301-918A_HPK1_Q92918-1_Rabbit_PDP.jpeg)
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