Thermo Fisher Scientific HPK1 Polyclonal Antibody
HPK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제됨. 인간 시료 반응성, 액상 형태, 4°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human hematopoietic progenitor kinase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
MAP4K1 (also known as HPK1, Hematopoietic progenitor kinase 1) is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase superfamily.
It acts as a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway and negatively regulates T cell receptor (TCR) signaling and T cell proliferation by phosphorylating SLP-76.
HPK1 is expressed predominantly in hematopoietic cells, including early progenitor cells, and specifically activates JNK1, enhancing AP-1-mediated transcriptional activity.
Unlike PAK65, HPK1 does not bind Rac1 or Cdc42, indicating a distinct regulatory mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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