Thermo Fisher Scientific KCNH2 (HERG) (extracellular) Polyclonal Antibody, FITC

Thermo Fisher Scientific KCNH2 (HERG) (extracellular) Polyclonal Antibody, FITC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 1:25

Species Reactivity

• Human
• Rat

Host / Isotype

• Rabbit / IgG

Class

• Polyclonal

Type

• Antibody

Immunogen

AFLLKETEEGPPATEC corresponding to residues 430–445 of human KV11.1 (HERG), extracellular region between S1 and S2 domains.

Conjugate

• FITC (Fluorescein)

Excitation / Emission Max

• 498 / 517 nm

Form

• Lyophilized

Concentration

• 1 mg/mL

Purification

• Antigen affinity chromatography

Storage Buffer

• PBS, pH 7.4, with 1% BSA

Contains

• 0.05% sodium azide

Storage Conditions

• Store at −20°C
• Avoid freeze/thaw cycles
• Store in dark

Shipping Conditions

• Ambient (domestic)
• Wet ice (international)

Product Specific Information

Reconstitute with 50 µL double distilled water (DDW), depending on sample size.
Ships as lyophilized powder at room temperature.
Upon arrival, store at −20°C.
Reconstituted solution can be stored at 4°C for up to 1 week.
For longer storage, aliquot and keep at −20°C.
Avoid multiple freeze/thaw cycles.
Centrifuge antibody preparations before use (10,000 × g, 5 min).

Target Information

Human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr.
Two N-terminal splice variants exist: isoform 1α (full-length) and isoform 1β (shorter, lacking PAS motif).
Isoform 1β deactivates faster than 1α.
C-terminal residues are involved in channel expression and gating, including voltage-dependent activation.
HERG is expressed in the heart, predominantly in ventricles.
Mutations in HERG cause beat-to-beat variability and early after-depolarization, contributing to long QT syndrome type 2 and short QT syndrome type 1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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