Thermo Fisher Scientific KCNH2 (HERG) (extracellular) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitution:
  Reconstitute with 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
  The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
  Reconstituted solution can be stored at 4°C for up to 1 week. For long-term storage, aliquot and store at -20°C.
  Avoid multiple freeze/thaw cycles.
  Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

The HERG (human ether-a-go-go related gene) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel (IKr).
Two N-terminal splice variants exist: isoform 1α (full-length) and isoform 1β (shorter, lacking PAS motif).
Isoform 1β deactivates faster than isoform 1α.
C-terminal residues influence channel expression and gating, including voltage-dependent activation.
HERG is predominantly expressed in cardiac ventricles.
Mutations in HERG are linked to long QT syndrome type 2 and short QT syndrome type 1, contributing to arrhythmogenic events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.