Thermo Fisher Scientific Phospho-IL4R (Tyr497) Polyclonal Antibody
IL4R 인산화 부위(Tyr497)를 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Human 및 Mouse 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human IL-4R/CD124 around the phosphorylation site of Tyr497 (P-A-YP-R-S) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco's PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555209 |
Target Information
IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine, and mucus production at sites of allergic inflammation.
The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha (sIL4R alpha) can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells, and it has no signaling abilities.
Allelic variations in the IL4RA gene have been associated with atopy, which may manifest as allergic rhinitis, sinusitis, asthma, or eczema.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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