Thermo Fisher Scientific CRYAA Monoclonal Antibody (OTI3B12), TrueMAB
CRYAA 단백질을 인식하는 Mouse monoclonal 항체로 Western Blot, IHC, ICC/IF에 사용 가능. Human 시료 반응성. Lyophilized 형태로 제공되며, 재구성 후 약 1 mg/mL 농도. 렌즈 단백질 연구 및 단백질 응집 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B12 |
| Immunogen | Full length human recombinant protein of human CRYAA produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Lens proteins consist almost entirely of crystallins (about 95%), which are also present in vertebrate skeletal muscle. In the lens, crystallins maintain the proper refractive index.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.
- Alpha-crystallin: largest class, composed of alpha-A and alpha-B gene products; comprises ~40% of total lens protein.
- Functions as a molecular chaperone, preventing protein aggregation that may lead to cataract formation.
- Phosphorylation states of alpha-crystallin may respond to cellular stress, serving structural control and protein maintenance roles.
- Alpha-B crystallin has been associated with Alexander’s disease, where it accumulates in brain cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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