Thermo Fisher Scientific TIN2 Recombinant Rabbit Monoclonal Antibody (5G11)
Recombinant Rabbit Monoclonal Antibody (Clone 5G11) targeting TIN2 protein. Validated for Western blot applications in human, mouse, and rat samples. High purity via affinity chromatography, supplied as liquid in PBS with glycerol. Suitable for telomer...
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Applications
- Western Blot (WB): Tested dilution 1:500–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5G11 |
| Immunogen | A synthesized peptide derived from human Tin2 (amino acids 210–309, UniProt ID: Q9BSI4-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.14 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898341 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
TRF1 is a negative regulator of telomere length maintenance. Two proteins, tankyrase and Tin2, bind to mammalian TRF1. Tankyrase localizes to telomeres by binding to TRF1 through its ankyrin repeats and exhibits PARP activity, functioning in ADP-ribosylation. ADP-ribosylation of TRF1 reduces its DNA-binding ability, suggesting regulation of telomere function via poly(ADP)-ribosylation.
TIN2 was identified as a TRF1-interacting partner from a yeast two-hybrid screening. It localizes to telomeres and is essential for telomere length regulation. Both TIN2 and TRF1 are constitutively expressed, acting together to counterbalance telomerase-mediated elongation. However, endogenous expression levels are low, making visualization by immunostaining challenging in some systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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