Thermo Fisher Scientific SDHB Recombinant Rabbit Monoclonal Antibody (7D12)
SDHB 단백질을 인식하는 토끼 단클론 항체로, Western blot, IHC, Flow cytometry에 적합. 인간, 마우스, 랫트 시료 반응. HEK293 세포에서 발현된 재조합 항체로 높은 특이성과 재현성 제공. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:200 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7D12 |
| Immunogen | A synthesized peptide derived from human SDHB (amino acids 227–241, UniProt ID: P21912-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.19 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C or –80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898337 |
Product Specific Information
This antibody has been tested in direct ELISA assays.
Target Information
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, supporting a link between mitochondrial dysfunction and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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