Thermo Fisher Scientific MNK1 Recombinant Superclonal Antibody (6HCLC)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Mouse, and Cat.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are composed of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies, while maintaining consistent recombinant production.

These antibodies recognize multiple epitopes on the target, ensuring high detection sensitivity for low-abundance targets. Each lot is produced with the same known mixture of light and heavy chains, eliminating biological variability seen in polyclonal antibody production.

Note: Formerly called “Recombinant Polyclonal Antibody”, this product is now rebranded as “Recombinant Superclonal™ Antibody”. The physical product and performance remain unchanged.

Target Information

The MAP kinase-interacting kinases (MNK1 and MNK2) are activated by MAP kinases and regulate protein synthesis by phosphorylating eIF4E on Ser209, potentially contributing to tumorigenesis. Overexpression of MNK2 increases phosphorylation of eIF-4E, indicating its role as an eIF-4E kinase in vivo.

MNK2 may be involved in responses to environmental stress and cytokines. Expression of active mutants of MNK1 and MNK2 in 293 cells reduces cap-dependent translation relative to cap-independent translation. Human MNK2 is ~94% identical to murine MNK2 and ~71% identical to human MNK1. In vitro studies show MNK2 is a better substrate than MNK1 for Erk2, p38MAPKα, and p38MAPKβ.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.