Thermo Fisher Scientific Phospho-MAPKAP1 (Thr86) Recombinant Superclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Rat, Cat, and Mouse.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They combine multiple recombinant monoclonal antibodies, providing both the sensitivity of polyclonal antibodies and the specificity of monoclonal antibodies, with the consistency of recombinant production.
These antibodies recognize multiple epitope sites, offering higher detection sensitivity for low-abundance targets. The recombinant Superclonal™ format ensures reproducibility across lots by using a defined mixture of light and heavy chains.
Note: Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. The product and performance remain unchanged.

Target Information

Sin1 was initially identified as the human homolog of S. pombe SIN1. It is identical to Mip1, which interacts with MEKK2, a member of the MAPK signaling network.
MAPKAP1 prevents MEKK2 activation and dimerization by forming a complex with inactive MEKK2, thereby blocking JNK1/2, ERK1/2, p38, and ERK5 MAPKs.
MAPKAP1 also participates in the TOR signaling pathway, controlling cell growth and proliferation in response to nutrients and growth factors. It maintains the TOR/rictor complex, enabling specific phosphorylation of Akt, linking PI3K signaling to nutrient-regulated TOR activity.
Multiple alternatively spliced isoforms of MAPKAP1 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.