Thermo Fisher Scientific ATGL Polyclonal Antibody
Human ATGL 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(Paraffin) 검증됨. 고순도 Affinity chromatography 정제, 액상형, 1 mg/mL 농도. 지방분해 효소 연구 및 에너지 항상성 관련 연구용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human Adipose Triglyceride Lipase aa 450–504 (Lumenal) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913500 |
Product Specific Information
- Positive Control: 293 cell lysate, HepG2 cell lysate, A431 cell lysate, human pancreas tissue
- Subcellular Location: Cell membrane, Lipid droplet
Target Information
Lipolytic enzymes are essential for mobilizing fatty acids from triglyceride stores in adipose tissue. Dysfunctional lipolysis affects energy homeostasis and may contribute to obesity and insulin resistance.
Hormone-sensitive lipase (HSL) was previously known as the sole triglyceride-hydrolyzing enzyme, but adipose triglyceride lipase (ATGL) is now recognized as catalyzing the initial step in triglyceride hydrolysis.
ATGL is highly expressed in adipose tissue of mice and humans, exhibits high substrate specificity for triacylglycerol, and associates with lipid droplets. Inhibition of ATGL significantly reduces total adipose acyl-hydrolase activity, indicating that ATGL and HSL coordinately catabolize stored triglycerides in mammalian adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-119928_ATGL_Q96AD5-1_Rabbit.svg, PA5-119928_ATGL_Q96AD5-1_Rabbit_PDP.jpeg)
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