Thermo Fisher Scientific WWTR1 Polyclonal Antibody
WWTR1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB, IHC, ICC/IF 등에 사용 가능. Hippo signaling pathway 연구에 적합하며, 높은 특이성과 재현성을 제공. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within human TAZ aa 1–200/400 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913499 |
Product Specific Information
- Positive Control: Human placenta tissue lysate, 293T cell lysate, human kidney tissue, mouse brain tissue, A549, HT-29
- Subcellular Location: Cell membrane, Cytoplasm, Membrane, Nucleus
Target Information
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator that acts as a downstream regulatory target in the Hippo signaling pathway. This pathway plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
The core of this pathway includes a kinase cascade involving STK3/MST2 and STK4/MST1, which, with SAV1, activates LATS1/2 and MOB1. MOB1 then phosphorylates and inactivates YAP1 and WWTR1/TAZ.
WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation, regulates nuclear accumulation of SMADS, and couples them to the transcriptional machinery such as the mediator complex. It also regulates embryonic stem-cell self-renewal, promotes cell proliferation, and drives epithelial-mesenchymal transition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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