Thermo Fisher Scientific CD33 Monoclonal Antibody (P67.6), PE-Cyanine7, eBioscience
인간 CD33 단백질을 인식하는 P67.6 단클론 항체로, PE-Cyanine7 형광체가 결합되어 있습니다. 유세포분석(Flow Cytometry)에 최적화되어 있으며, 고순도의 액상 형태로 제공됩니다. 4°C 암소 보관하며, 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific CD33 Monoclonal Antibody (P67.6), PE-Cyanine7, eBioscience™
Applications
- Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.125 µg)/test
- Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE-Cyanine7, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | P67.6 |
| Conjugate | PE-Cyanine7 |
| Excitation / Emission Max | 569 / 780 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848301 |
Available Formats
Product Specific Information
The P67.6 monoclonal antibody reacts with human CD33 (GP67, P67), a 67 kDa type I transmembrane glycoprotein belonging to the Siglec (sialic acid-binding Ig superfamily lectin) family. CD33 is expressed in the hematopoietic compartment, including monocytes, activated T cells, granulocytes, myeloid progenitors, and mast cells.
Applications Reported:
- Flow cytometric analysis
Applications Tested:
- Pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells
- Recommended usage: 5 µL (0.125 µg) per test in a final volume of 100 µL (10⁵–10⁸ cells/test)
Handling Notes:
- Light sensitivity: Protect from light due to photo-induced oxidation sensitivity
- Fixation: Samples can be stored in IC Fixation Buffer (Product #00-8222-49) or 1-step Fix/Lyse Solution (Product #00-5333-57) for up to 3 days at 4°C in the dark
- Excitation/Emission: 488–561 nm / 775 nm
- Compatible Lasers: Blue, Green, Yellow-Green Lasers
Target Information
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit SHP-1 and SHP-2 phosphatases and regulate receptor signaling.
CD33 is expressed on cells of the myelomonocytic lineage, including granulocyte and macrophage precursors, and is a therapeutic target for acute myeloid leukemia (AML). It is also a useful marker for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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