Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI11B2), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

T lymphocytes initiate cell-mediated immune responses when stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express inhibitory receptors such as PD-1 (PDCD1), which modulate immune activation through interactions with ligands PDL-1 and PDL-2.
Upon ligand binding, PD-1 transmits inhibitory signals that suppress immune activation in the absence of danger signals (e.g., LPS).
PD-1 deficiency in mice leads to hyperactivated immune systems and autoimmune disease.
Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.