Thermo Fisher Scientific GPR65 Polyclonal Antibody
Human GPR65 단백질을 인식하는 Rabbit Polyclonal Antibody로 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 보존. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 4–11 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from 1st cytoplasmic domain of human GPR65 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2263598 |
Product Specific Information
PA1-32515 detects GPR65 from human samples.
Target Information
GPR65 (also known as TDAG8) is a transmembrane protein belonging to the G protein-coupled receptor superfamily. It consists of 337 amino acids and shares 90% similarity and 81% identity in the seven transmembrane domains with its mouse homolog.
It has three potential N-linked glycosylation sites and is predominantly expressed in lymphoid organs and cancer tissues, with increased expression during activation-induced death of T-cell hybridomas.
Two major transcripts (4.5 kb and 1.8 kb) are found in peripheral blood leukocytes. GPR65 functions as a proton-sensing receptor, coupling to adenylyl cyclase and psychosine, and is involved in the establishment of immunological autotolerance.
It also plays a role in cellular transformation through RhoA activation and actin rearrangement under conditions of tissue acidosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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