Thermo Fisher Scientific MSLN Monoclonal Antibody (OTI1G8), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Mesothelin (MSLN) was originally identified as a differentiation antigen of mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas. It is a glycosylphosphatidylinositol (GPI)-anchored, cell-surface glycoprotein secreted by mesothelial cells.
While its expression is limited in normal tissues, aberrant overexpression occurs in various cancers including endometrioid uterine adenocarcinomas and squamous cell carcinomas of the esophagus, stomach, lung, and cervix.

Proteolytic cleavage of Mesothelin yields a soluble fragment known as megakaryocyte potentiating factor (MPF), which stimulates megakaryocyte colony formation in murine bone marrow cultures. Both Mesothelin and MPF are implicated in tumorigenesis, promoting tumor cell proliferation, migration, and metastasis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.