Thermo Fisher Scientific TSC2 Polyclonal Antibody
인간 TSC2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 고순도 Protein A 및 항원 친화 크로마토그래피로 정제됨. 0.5 mg/mL 농도의 액상 형태로 제공되며, 장기 보관 시 -20°C 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 1776–1805 amino acids from human Tuberin (TSC2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981291 |
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2) is implicated as a tumor suppressor and may function in vesicular transport, play a role in the regulation of cell growth arrest, and in transcription mediated by steroid receptors.
TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Phosphorylation of tuberin on Ser 939 and Thr 1462 regulates its interaction with hamartin and is stimulated by various growth factors through the phosphoinositide 3-kinase/Akt pathway.
TSC2 may also play a role in vesicular docking and stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5, suggesting a mechanism for its role in regulating cellular growth.
Mutations in TSC2 lead to constitutive activation of RAP1A in tumors and are involved in diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma. Alternative splicing results in transcript variants of three different isoforms of TSC2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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