Thermo Fisher Scientific alpha Synuclein Polyclonal Antibody
Rabbit polyclonal antibody against human alpha-synuclein for WB and IHC applications. Recognizes C-terminal region (aa 75–104) of SNCA. Supplied as liquid, 0.5 mg/mL in PBS with 0.09% sodium azide. Suitable for research on Parkinson’s and Alzheimer’s d...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 75–104 of the C-terminal region of human SNCA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2192675 |
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play roles in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways. Defects in the SNCA gene, encoding alpha-synuclein, are implicated in Parkinson’s disease pathogenesis. Alpha-synuclein peptides are also a major component of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia with Lewy Bodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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