Thermo Fisher Scientific p27 Kip1 Polyclonal Antibody
p27 Kip1 단백질을 표적하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에서 IHC(P) 검증됨. 세포주기 조절 연구에 적합하며, 비결합형 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific p27 Kip1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 9 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
| Flow Cytometry (Flow) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from C-terminal of human p27Kip1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_10977242 |
Product Specific Information
PA5-16717 targets p27Kip1 in IHC (P) applications and shows reactivity with Human, Mouse, and Rat samples.
The immunogen is a synthetic peptide derived from the C-terminal region of human p27Kip1.
Target Information
p27 Kip1 functions as a negative regulator of G1 phase expression and may mediate TGFβ-induced G1 arrest.
It is a key regulator of cell cycle progression and a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes.
p27 Kip1 forms complexes with cyclin D-CDK4 and is involved in assembly, stability, and modulation of CCND1-CDK4 activation.
Depending on phosphorylation state, p27 Kip1 can act as either inhibitor or activator of cyclin D-CDK4 complexes.
This protein (~27 kDa) undergoes CDK-dependent phosphorylation and ubiquitination by SCF complexes, enabling transition from quiescence to proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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