Thermo Fisher Scientific CTNNA3 Polyclonal Antibody

Thermo Fisher Scientific CTNNA3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive test controls: LO2, 293T, Mouse spleen, Rat brain
• Localization: Cytoplasm, cytoskeleton

Immunogen sequence:
MKSTQRREKQ GSMSAETPIT LNIDPQDLQV QTFTVEKLLE PLIIQVTTLV NCPQNPSSRK KGRSKRASVL LASVEEATWN LLDKGEKIAQ EATVLKDELT ASLEEVRKES EALKVSAERF TDDPCFLPKR EAVVQAARAL LAAVTRLLIL ADMIDVMCLL QHVSAFQRTF ESLKNVANKS DLQKTYQKLG KELENLDYLA FKRQQDLKSP NQRDEIAGAR ASLKENSPLL HSICSACLEH

Target Information

Catenins are proteins that connect cadherin/beta-catenin cell adhesion complexes to the actin cytoskeleton. Although originally discovered in testis, alphaT-catenin is also expressed in other tissues, with the highest levels observed in the heart. Immunohistochemical analysis shows human alphaT-catenin localization at intercalated discs of cardiomyocytes and in peritubular myoid cells of testis.
AlphaT-catenin can functionally restore cell-cell adhesion in colon cancer cells lacking alpha-catenins, indicating its role in forming specific cell-cell contacts in muscle cells. The encoded protein has a predicted size of approximately 100 kDa, with 57% amino acid identity to other alpha-catenins.
In cells transfected with alphaT-catenin cDNA, interaction with alpha-catenin was demonstrated by coimmunoprecipitation. The 892_24D2S antibody against alphaT-catenin does not cross-react with alphaE-catenin or alphaN-catenin in western blot analysis.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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