Thermo Fisher Scientific mGluR7 Monoclonal Antibody (7G8D3)
mGluR7 단백질을 인식하는 Mouse monoclonal antibody. Western blot, ICC/IF, Flow cytometry, ELISA에 사용 가능. Human 시료 반응성 검증됨. Protein G 정제, 1 mg/mL 농도, PBS buffer에 sodium azide 포함. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7G8D3 |
| Immunogen | Purified recombinant fragment of human GRM7 (AA: 454–590) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787377 |
Product Specific Information
MA5-31754 has been tested in indirect ELISA.
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system, activating both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is essential for normal brain function and can be altered in various neuropathologic conditions.
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors divided into three groups based on sequence homology, signal transduction, and pharmacologic properties:
- Group I: GRM1, GRM5 (activate phospholipase C)
- Group II: GRM2, GRM3
- Group III: GRM4, GRM6, GRM7, GRM8
Groups II and III are linked to inhibition of the cyclic AMP cascade but differ in agonist selectivity. Multiple transcript variants encoding different isoforms exist for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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