Thermo Fisher Scientific mGluR8 Monoclonal Antibody (4C1C1)
인간 GRM8 단백질을 인식하는 mGluR8 단클론 항체로, Western blot, Flow cytometry, ELISA에 적합합니다. 단클론(Mouse/IgG1) 형식이며, Protein G로 정제된 액상형 항체입니다. 4°C 단기 보관, -20°C 장기 보관 권장.
- 카탈로그번호
- MA531755
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C1C1 |
| Immunogen | Purified recombinant fragment of human GRM8 (AA: 440–583) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787378 |
Product Specific Information
MA5-31755 has been tested in indirect ELISA.
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.
The metabotropic glutamate receptors are a family of G protein-coupled receptors divided into three groups based on sequence homology, signal transduction mechanisms, and pharmacologic properties:
- Group I: GRM1, GRM5 — activate phospholipase C
- Group II: GRM2, GRM3
- Group III: GRM4, GRM6, GRM7, GRM8 — linked to inhibition of the cyclic AMP cascade, differing in agonist selectivities
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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