Thermo Fisher Scientific TGM2 Polyclonal Antibody
TGM2 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot에 적합하며 Mouse, Rat 시료에 반응. 0.5 mg/mL 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- PA5142800
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-ERDLYLENPEIKIR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933443 |
Product Specific Information
- This antibody is expected to recognize isoform a (NP_004604.2) only.
- Tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
Target Information
Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for activity.
In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase, TGase 2) consists of four domains: an N-terminal β-sandwich, a catalytic core, and two C-terminal β-barrel domains.
tTGase is implicated in cell death, proliferation, differentiation, and receptor-mediated endocytosis. In Alzheimer’s disease, elevated tTGase activity leads to polymerization of proteins such as Aβ peptide, β-amyloid precursor protein, and tau, contributing to neurofibrillary tangle formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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