Thermo Fisher Scientific CD44 Recombinant Rabbit Monoclonal Antibody (ST57-03)
Recombinant rabbit monoclonal antibody for CD44 detection. Validated in WB and IHC (Paraffin). High specificity and purity with Protein A purification. Supplied in liquid form, 1 mg/mL, stored at 4°C or -20°C. For research use only.
- 카탈로그번호
- MA541144
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ST57-03 |
| Immunogen | Synthetic peptide within human CD44 aa 150–190 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898898 |
Target Information
CD44 is a 100 kDa type I transmembrane glycoprotein expressed on human leukocytes, white matter of the brain, and some epithelial cells. It serves as a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration. CD44 plays roles in lymphocyte activation, recirculation, and homing, and its expression is often upregulated in carcinomas, potentially linked to metastatic potential.
CD44 is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 upon stimulation. The CD44 gene undergoes complex alternative splicing, producing multiple isoforms with distinct functions. Dysregulation of CD44 has been associated with diseases such as superficial keratitis and lichen sclerosus and may contribute to tumor metastasis formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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